The Role of Pyridoxine in the Prevention and Treatment of Neuropathy and Neurotoxicity Associated with Rifampicin-Resistant Tuberculosis Treatment Regimens: A Topic Review

Rifampicin-resistant tuberculosis (RR-TB) is a global public health problem caused by mycobacterium resistant to Rifampicin. Drug-induced peripheral neuropathy and neurotoxicity are well-known adverse effects of treatment regimens that cause significant morbidity. Pyridoxine often added for the prevention and/or these side effects. The basis effectiveness this practice unclear. We conducted systematic review evaluate pyridoxine in preventing treating associated with RR-TB treatment. included studies patients who experienced or attributed were given pyridoxine. Our findings showed contradicting evidence on use due cycloserine RR-TB. Moreover, did not have protective effect against other do contain isoniazid. In conclusion, we found withdrawing withholding medications such as linezolid, cycloserine, thioamides, fluoroquinolones, ethambutol, implicated causing was more effective than using stop progression symptoms, some instances, led their reversal over time.